Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, anapoptosisinducer, anticancer, anti-angiogenic, and antiproliferative. IC50 value: Target: microtubule Tubulysin A is a novelantibiotic, which is anti-microtubule, anti-mitotic,apoptosisinducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxicpeptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.

844.07

C₄₃H₆₅N₅O₁₀S

205304-86-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.