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Propargyl-PEG7-acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Propargyl-PEG7-acid图片
CAS NO:2093154-00-6
包装与价格:
包装价格(元)
100mg电议
250mg电议

产品介绍
Propargyl-PEG7-acid 是一种 PROTAC 连接桥,属于 PEG 类。Propargyl-PEG7-acid 可用于合成一系列 PROTAC 分子。Propargyl-PEG7-acid 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。
Cas No.2093154-00-6
分子式C18H32O9
分子量392.44
储存条件4°C, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Propargyl-PEG7-acid is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs. Propargyl-PEG7-acid is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.