Duocarmycin DM, aDNA minor-groove alkylator, is an antibody drug conjugates (ADCs) toxin. Duocarmycin DM is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity^[1][2].

The Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated fromStreptomyces sp.that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture^[2].
Duocarmycin DM shows cytotoxicity to several human cancer cells, with IC₅₀of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively^[3].

577.98

C₂₈H₂₇ClF₃N₃O₅

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.