Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibitstubulinpolymerization.

Dolastatin 10 is a unique pentapeptide that isolated from the sea hareDolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI₅₀values of 10^–5-10^–6μg/mL (10^–2-10^–3nM) against a similar minipanel of human cell lines^[2]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10^[3].

785.09

Solid

C₄₂H₆₈N₆O₆S

110417-88-4

尾海兔素10

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Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

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DMSO : ≥ 100 mg/mL(127.37 mM)

*"≥" means soluble, but saturation unknown.

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