SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

SGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates^[1]. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I^[2].

725.79

Solid

C₄₂H₃₉N₅O₇

1222490-34-7

Room temperature in continental US; may vary elsewhere.

DMSO : 100 mg/mL(137.78 mM;Need ultrasonic)

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