(Rac)-Efavirenz-d4 ((Rac)-DMP 266-d4) is a labelled racemic Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-typeHIV-1reverse transcriptasewith aK_iof 2.93 nM and exhibits anIC₉₅of 1.5 nM for the inhibition ofHIV-1replicative spread incell culture^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

319.70

C₁₄H₅D₄ClF₃NO₂

1246812-58-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.