Asimilobine

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Asimilobine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

6871-21-2

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品名称

巴婆碱

产品介绍

Asimilobine 是从木兰的植物中分离出的一种阿朴啡型异喹啉生物碱。Asimilobine 是多巴胺 (dopamine) 生物合成的抑制剂，也是血清素能受体 (serotonergic receptor) 拮抗剂。Asimilobine 具有抗疟 (antimalarial) 和抗癌活性。

生物活性

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species ofMagnolia obobataThun. Asimilobine is adopaminebiosynthesis inhibitor and aserotonergic receptorantagonist. Asimilobine shows anantimalarialand anti-cancer activity^[1]^[2].

IC₅₀& Target^[1]^[2]

Plasmodium

Dopamine Receptor

serotonergic receptor

体外研究
(In Vitro)

Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC₅₀value of 0.13 μM^[2].
Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h^[2].
Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels^[2].

分子量

267.32

Formula

C₁₇H₁₇NO₂

CAS 号

6871-21-2

中文名称

巴婆碱

结构分类

Alkaloids
Isoquinoline Alkaloids

Phenols
Monophenols

来源

Plants
Nymphaeaceae
Nelumbo nuciferaGaertn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.