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UCB7362
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UCB7362图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
UCB7362 是一种口服有效的抗疟疾 (antimalarial) plasmepsin X (PMX) 抑制剂,其IC50为 7 nM。UCB7362 可抑制寄生虫 (parasite) 生长。
生物活性

UCB7362 is an orally active and potentantimalarialplasmepsin X (PMX) inhibitor, with anIC50of 7 nM. UCB7362 inhibitsparasitegrowth[1].

IC50& Target

Plasmodium

 

体外研究
(In Vitro)

UCB7362 is substantially more potent against PMX than PMIX with an IC50of 7 nM for the former compared to 142 nM for the latter[1].
UCB7362 also demonstrates an improvement in selectivity against Cat D and Renin with an IC50of 3889 nM and >10,000 nM, respectively[1].

体内研究
(In Vivo)

UCB7362 (10-60 mg/kg, Oral administration, twice a day, for 4 days) clears parasitemia from peripheral blood[1].
UCB7362 (IV (1 mg/kg), PO (10 mg/kg); once) shows moderate clearance in dog and cynomolgus monkey and moderate-high in rat[1].

Animal Model:Pf (Plasmodium falciparum) SCID mouse model[1]
Dosage:10, 25 and 60 mg/kg
Administration:Oral administration, twice a day, for 4 days, with the second administration 10 h after the first one
Result:Cleared parasitemia from peripheral blood in a dose-dependent manner.
Animal Model:Sprague Dawley rat[1]
Dosage:1 mg/kg, 10 mg/kg
Administration:IV (1 mg/kg), PO (10 mg/kg); once (Pharmacokinetic Analysis)
Result:Pharmacokinetic Parameters of UCB7362 in Sprague-Dawley rats[1].
IV (1 mg/kg)PO (10 mg/kg)
CL (mL/(min kg))43.9
Vss (L/kg)5.72
Tmax(h)3
Cmax(nM)246
AUC0-24(nM*h)7931410
t1/2(h)2.1
F (%)11
分子量

479.96

Formula

C25H26ClN5O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.