Warangalone is an anti-malarial compound which can inhibit the growth of both strains ofparasite3D7(chloroquine sensitive) andK1(chloroquine resistant) withIC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibitcyclic AMP-dependent protein kinase catalytic subunit(cAK) with anIC₅₀of 3.5 μM.

Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively^[1]. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀of 3.5 μM^[2]. When HL-60 cells are exposed to Warangalone (30 μM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells^[3].

404.46

Solid

C₂₅H₂₄O₅

4449-55-2

攀登鱼藤异黄酮

• Flavonoids
• Isoflavones

• Phenols
• Polyphenols

• Plants
• Leguminosae
• Erythrina variegataLinn.

Room temperature in continental US; may vary elsewhere.