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Homobutein
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Homobutein图片
CAS NO:34000-39-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Homobutein 是一种天然查尔酮 (可存在于许多药用植物、水果、蔬菜、香料和坚果中) 和有效的 HDACs/NF-κB 双重抑制剂,其IC50值分别为 190 和 38 μM。Homobutein 也是一种铁离子 (II 和 III) 螯合剂,具各种活性,包括抗癌,抗炎,抗寄生虫和抗氧化活性。
生物活性

Homobutein a naturalchalcones(can be found in many medicinalplants, fruits, vegetables, spices and nuts), is a potentHDACs/NF-κBdual inhibitor withIC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4].

IC50& Target

Toxoplasma

 

体外研究
(In Vitro)

Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells[1].
Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells[1].
Homobutein (1 μg/mL; 72 h) inhibits the growth ofToxoplasma gondiiby 19.48%[2].
Homobutein (24 h) againsts W2 and D6 strains ofP.falciparumwith IC50s of 15.0 and 16.1 μM, respectively[3].

Cell Viability Assay[1]

Cell Line:K562 cells
Concentration:20, 24, 28, 32, 40 μM
Incubation Time:2 h
Result:Showed inhibition of viability in K562 cells.

Cell Viability Assay[2]

Cell Line:Toxoplasma gondiiRH-2F strain
Concentration:1 μg/mL
Incubation Time:72 h
Result:Surpressed 19.48% of theToxoplasma gondii.
分子量

286.28

Formula

C16H14O5

CAS 号

34000-39-0

结构分类
  • Flavonoids
  • Chalcones
  • Phenols
  • Polyphenols
来源
  • Plants
  • Compositae
  • Wedelia asperrima(Gardner) B.L.Turner
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.