Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibitsP. falciparum(IC₅₀=50 nM) andA. baumanii(IC₅₀=390 nM)^[1].

Antimalarial agent 18 (compound 13j) is the long chain octanoyl analog, shows cytotoxicity against MRC-5 fibroblasts with an IC₅₀value of 40.3 μM^[1].
Antimalarial agent 18 poorly inhibits avirulentM. tuberculosisstrain (H37Ra) with an IC₅₀value >64 μM^[1].
Antimalarial agent 18 may serve as a lead for future analog development of MEP pathway inhibitors against Gram-negative pathogens in general, andA. baumanniiin particular^[1].

509.57

C₂₃H₄₄NO₉P

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