| CAS NO: | 51781-21-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 25mg | 电议 |
| 100mg | 电议 |
| Cas No. | 51781-21-6 |
| 别名 | 盐酸卡替洛尔; OPC-1085 hydrochloride |
| 化学名 | 5-(3-(tert-butylamino)-2-hydroxypropoxy)-3,4-dihydroquinolin-2-ol hydrochloride |
| Canonical SMILES | CC(C)(NCC(O)COC1=CC=CC2=C1CCC(O)=N2)C.Cl |
| 分子式 | C16H25ClN2O3 |
| 分子量 | 328.83 |
| 溶解度 | ≥ 16.4mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Beta-adrenergic antagonist are an important class of drugs for the treatment of various heart diseases, such as high blood pressure, insufficiency of blood flow to the heart muscle, irregular heart beat, thickened heart muscle, and decreased ability of the heart to empty or fill normally. β-Blockers can also be used to treat migraine headache and increased eye pressure (glaucoma). Carteolol is a nonselective beta-adrenoceptor antagonist. In vitro: Previous findings demonstrate that carteolol, unlike xamoterol, is a nonconventional partial agonist, which causes agonistic effects via interaction with the low-affinity propranolol-resistant site of β1-adrenoceptors and antagonistic actions by the high-affinity site of the same receptors [1]. In vivo: Both 8-OH carteolol and carteolol suppressed the water-load induced intraocular pressure (IOP) rise in rabbits. 8-OH carteolol was more effective in suppressing water-load induced IOP rise in rabbits compared with carteolol on equimolar basis. Both 8-OH carteololand carteolol caused a significant decrease in IOP in monkeys. 8-OH carteolol was estimated to be more potent than carteolol in lowering IOP on equimolar basis in monkeys [2]. Clinical trial: The new alginate formulation of long-acting carteolol 1% given once daily is as effective as standard 1% carteolol given twice daily, with no meaningful differences regarding safety. The new alginate formulation of long-acting 1% carteolol given once a day is effective and well tolerated by glaucoma patients requiring chronic treatment [3]. Reference: |
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