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Erythromycin A enol ether
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Erythromycin A enol ether图片
CAS NO:33396-29-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
红霉素A烯醇醚是红霉素A(大环内酯类抗生素)的酸性降解产物,无抗菌作用。
Cas No.33396-29-1
别名红霉素 A 烯醇醚
化学名8,9-didehydro-9-deoxo-6-deoxy-6,9-epoxy-erythromycin
Canonical SMILESO=C1[C@@H]([C@H]([C@@H]([C@]([H])([C@]2(CC(C)=C([C@@H]([C@H]([C@@](C)([C@H](O1)CC)O)O)C)O2)C)O[C@]3([C@@H]([C@H](C[C@H](O3)C)N(C)C)O)[H])C)O[C@@]4(O[C@H]([C@@H]([C@@](C)(C4)OC)O)C)[H])C
分子式C37H65NO12
分子量715.9
溶解度≤30mg/ml in DMSO;15mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Erythromycin A enol ether, also known as 8,9-anhydroerythromycin A 6,9 hemiketal, is a kind of catabolite of erythromycin A without its antibiotic properties.

Erythromycin A enol ether functions as a β-turn mimic of the peptide hormone motilin which leads to duodenal contractions. Erythromycin A enol ether is also the agent of gastrointestinal (GI) distress [1].

Motilin is a kind of polypeptide hormone with 22-amino acid belonging to the motilin family. Motilin could increase the migrating myoelectric complex of gastrointestinal motility, and stimulate the pepsin production. Motilin could also improve peristalsis in the small intestine and empty the gut for the next meal. Besides, motilin could facilitate the release of somatostatin and pancreatic polypeptide.

In Vitro: No data available.

In Vivo: No data available.

Clinical trial: No data available.

Reference:
[1] Steinmetz W E, Shapiro B L, Roberts J J, et al.  The structure of erythromycin enol ether as a model for its activity as a motilide.[J]. Journal of Medicinal Chemistry, 2002, 45(22): 4899-4902.