| CAS NO: | 21898-19-1 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 21898-19-1 |
| 别名 | 盐酸克仑特罗,NAB 365,Ventipulmin |
| 化学名 | 4-amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]-benzenemethanol, monohydrochloride |
| Canonical SMILES | ClC1=CC(C(O)CNC(C)(C)C)=CC(Cl)=C1N.Cl |
| 分子式 | C12H18Cl2N2O o HCl |
| 分子量 | 313.7 |
| 溶解度 | ≥ 13.15mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Clenbuterol is a sympathomimetic β2-adrenoceptor agonist. β2-adrenoceptor agonists, mainly long-acting β2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease. In vitro: A hormone dependent human breast cancer cell line was treated with different concentrations of clenbuterol. It was found that clenbuterol could stimulate cell proliferation at low concentrations, but the effect was less marked and significant compared with oestradiol. Probably clenbuterol elicited cell proliferation via a different mechanism, because it did not affect the cellular oestrogen receptor concentration [1]. In vivo: Clenbuterol was administered to Fischer-344 rats, at a dose of 1.5 mg/kg/24 h for 3 weeks. The weights of five hindlimb muscles and carcass protein and fat content were determined. Results showed that clenbuterol treatment could increase the weight of skeletal muscles of all animals. Similarly, clenbuterol increased carcass protein conten, leading to the reduced carcass fat content [2]. Clinical trial: Clenbuterol was compared with terbutaline during a 5-week single-blind crossover study in patients with chronic airways obstruction. Both clenbuterol and terbutaline could significantly improve baseline FEV1 and the bronchodilator effects were similar, suggesting that clenbuterol was a good alternative drug for treatment of chronic airways obstruction [3]. References: |
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