| CAS NO: | 104113-71-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| Cas No. | 104113-71-5 |
| 别名 | 1-(1-萘基)哌嗪盐酸盐,1-NP |
| 化学名 | 1-(1-naphthalenyl)-piperazine, monohydrochloride |
| Canonical SMILES | C1(C(N2CCNCC2)=CC=C3)=C3C=CC=C1.Cl |
| 分子式 | C14H16N2o HCl |
| 分子量 | 248.7 |
| 溶解度 | ≥ 13.7mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 1-(1-Naphthyl) piperazine (1-NP) is a serotonergic ligand which could bind nonselectively with multiple serotonin (5-HT) receptors [1]. The serotonin receptors, also known as 5-HT receptors, belong to a family of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. The serotonin receptors have been involved in many biological and neurological processes, such as aggression, anxiety, cognition, learning, memory, and mood [2]. In vitro: 1-NP binds to human 5- HT6 (h5-HT6) serotonin receptors with a Ki of 120 nM [1]. In rat cortical membranes, 1-NP inhibited the activity of 5-HT1 and 5-HT2 with IC50 values of 6 and 1 nM, respectively. 1-NP also blocked contraction in the rat fundus induced by either 5-HT or tryptamine with an IC50 of 1 nM [3]. In vivo: In squirrel monkeys, 1-NP (0.3–1.0 mg/kg) blocked the decrease of responding under fixed-interval (FI) schedules of presentation of food caused by DOB (0.01–0.3 mg/kg), an agonist of 5-HT2. 1-NP also antagonized the decreases in responding produced by quipazine (0.1–5.6 mg/kg), another agonist with predominant 5-HT2 actions [4]. References: |
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