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Antiparasitic agent-9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Antiparasitic agent-9图片
CAS NO:2516237-50-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Antiparasitic agent-9 (compound 47) 是一种口服有效的抗寄生虫剂。Antiparasitic agent-9 显示对人类寄生虫的抗寄生虫活性。
生物活性

Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the humanparasite[1].

IC50& Target

Mite

 

体内研究
(In Vivo)

Antiparasitic agent-9 (compound 47) (15 mg/kg, Orally, twice each day for 7 days) reduces adult worm burden in the jirdL. sigmodontisinfection model[1].
Antiparasitic agent-9 (2 mg/kg (IV), 10 and 30 mg/kg (PO); once) shows a brain to plasma ratio of 0.08, suggesting limited brain exposure[1].
Pharmacokinetic Parameters of Antiparasitic agent-9 in male Male CD-1 mouse[1].

PO (30 mg/kg)PO (10 mg/kg)IV (2 mg/kg)
Cmax(μM)13.95.27 ± 0.83
Tmax(h)0.504.0 ± 2.8
AUC0-inf(μM·h)12168.1±NC
CL (mL/min/kg)3.6 ± 0.22
Vd ss (mL/kg)0.74 ± 0.08
F (%)57
brain/plasma [b]/[p]0.08
efflux ratio (ER)12

Animal Model:Female BALB/c mice (infected withL. sigmodontis, 6-8 weeks)[1]
Dosage:15 mg/kg
Administration:Orally, twice each day for 7 days
Result:Showed a significant worm burden reduction of 59% at 15 mg/kg.
Animal Model:Male CD-1 mouse (n = 4)[1]
Dosage:2 mg/kg (IV), 10 and 30 mg/kg (PO)
Administration:IV, PO, once (Pharmacokinetic Analysis)
Result:Showed a brain to plasma ratio of 0.08, suggesting limited brain exposure.
分子量

384.46

Formula

C18H20N6O2S

CAS 号

2516237-50-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.