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4-Phenoxybenzylamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-Phenoxybenzylamine图片
CAS NO:107622-80-0
包装:100mg
市场价:446元

产品介绍
4-Phenoxybenzylamine通过稳定无活性构象来抑制NS3蛋白的功能,抑制FLNS3/4a的IC50值约为500μM。
Cas No.107622-80-0
别名4-苯氧基苄胺
Canonical SMILESNCC1=CC=C(OC2=CC=CC=C2)C=C1
分子式C13H13NO
分子量199.25
溶解度Soluble in DMSO
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against FL NS3/4a.

A highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein is identified. 4-Phenoxybenzylamine binding at this allosteric site inhibits the function of the NS3 protein by stabilizing an inactive conformation and thus represents a new class of direct acting antiviral agents[1].

[1]. Saalau-Bethell SM, et al. Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function. Nat Chem Biol. 2012 Nov;8(11):920-5.