| CAS NO: | 109946-35-2 |
| 包装: | 25μg |
| 市场价: | 4820元 |
| Cas No. | 109946-35-2 |
| 别名 | 互变霉素 |
| Canonical SMILES | C[C@@H]([C@]([C@H](CC1)C)([H])O[C@@]1(CC[C@H]2C)O[C@H]2CC[C@H](C)C(C)=O)CC[C@H](O)[C@H](C)C(C[C@@H](O)[C@H](OC)[C@@H](C(C)C)OC(C[C@H](C(C(O3)=O)=C(C3=O)C)O)=O)=O |
| 分子式 | C41H66O13 |
| 分子量 | 766.96 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively[1][2]. MTC cell growth is inhibited in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].NE markers ASCL1 and CgA in human MTC cells are decreased in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].|| Cell Proliferation Assay[2]||Cell Line:|Human MTC cells|Concentration:|0-1000 nM|Incubation Time:|48 hours|Result:|Inhibited MTC cell growth in a dose-dependent manner.|| Western Blot Analysis[2]||Cell Line:|Human MTC cells|Concentration:|0-1000 nM|Incubation Time:|48 hours|Result:|Led to a dose-dependent decrease in the NE markers ASCL1 and CgA. [1]. MacKintosh C, et al. Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A. FEBS Lett. 1990 Dec 17;277(1-2):137-40. [2]. Adler JT, et al. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. Mol Cancer Ther. 2009 Apr;8(4):914-20. |
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