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Varespladib methyl(A-002)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Varespladib methyl(A-002)图片
CAS NO:172733-08-3
包装:1mg
市场价:2678元

产品介绍
Varespladibmethyl (A-002) (A-002; LY333013) 是 II 组分泌型磷脂酶 A2 (PLA2) 的选择性抑制剂。
Cas No.172733-08-3
别名A-002; LY333013
Canonical SMILESO=C(OC)COC1=CC=CC2=C1C(C(C(N)=O)=O)=C(CC)N2CC3=CC=CC=C3
分子式C22H22N2O5
分子量394.42
溶解度DMSO: 100 mg/mL (253.54 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Varespladib methyl is a selective inhibitor of group II secretory phospholipase A2 (PLA2).

Varespladib methyl (LY333013) is an orally-administered methyl ester pro-drug that is metabolized to LY315920[1]. Varespladib and its orally bioavailable prodrug, Varespladib methyl (methyl-Varespladib) shows high-level secretory PLA2 (sPLA2) inhibition at nanomolar and picomolar concentrations against 28 medically important snake venoms from six continents[2].

[1]. Bradley JD, et al. A randomized, double-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis. J Rheumatol. 2005 Mar;32(3):417-23. [2]. Lewin M, et al. Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. Toxins (Basel). 2016 Aug 25;8(9). pii: E248.