Tipranavir-d4 (PNU-140690-d4) is the deuterium labeled Tipranavir. Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization ofHIV-1protease, exerts potent activity against multi-protease inhibitor (PI)-resistantHIV-1isolates withIC₅₀s of 66-410 nM^[1][2]. Tipranavir inhibits SARS-CoV-2 3CL^proactivity^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

606.69

C₃₁H₂₉D₄F₃N₂O₅S

1217819-15-2

替拉那韦 d4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.