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Avagacestat(BMS-708163)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Avagacestat(BMS-708163)图片
CAS NO:1146699-66-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
Avagacestat (formerly known as BMS708163) is a potent, selective, orally bioactive γ -secretase inhibitor of Aβ40 and Aβ42 with potential anti-AD (Alzheimer's disease) activity. It inhibits Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, it demonstrated a 193-fold selectivity against Notch. Avagacestat is designed for selective inhibition of Aβ synthesis currently in development for the treatment of mild to moderate and predementia AD. Avagacestat produced up to 190-fold greater selectivity for Aβ synthesis than Notch processing in preclinical studies and may therefore produce less toxic adverse events than other less selective compounds.
理化性质和储存条件
Molecular Weight (MW)520.88
FormulaC20H17ClF4N4O4S
CAS No.1146699-66-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 104 mg/mL (199.7 mM)
Water:<1 mg/mL
Ethanol:<1 mg/mL
SMILESO=C(N)[C@H](N(CC1=CC=C(C2=NOC=N2)C=C1F)S(=O)(C3=CC=C(Cl)C=C3)=O)CCC(F)(F)F
SynonymsBMS-708163; BMS708163; Avagacestat; BMS 708163.

Chemical Name: (R)-2-(4-chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)phenylsulfonamido)-5,5,5-trifluoropentanamide

InChi Key: MKQKPLQMNCXTJE-VEZQGTPESA-L

InChi Code: InChI=1S/C22H25N6O8P.2Na/c1-2-23-22(29)27-19-16-20(25-11-24-19)28(12-26-16)21-18-17(14(34-21)10-33-37(30,31)32)35-15(36-18)9-8-13-6-4-3-5-7-13;;/h3-9,11-12,14-15,17-18,21H,2,10H2,1H3,(H2,30,31,32)(H2,23,24,25,27,29);;/q;2*+1/p-2/b9-8+;;/t14-,15+,17-,18-,21-;;/m1../s1