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ACH-806
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACH-806图片
CAS NO:870142-71-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
GS9132
产品介绍
ACH-806 是一种NS4A拮抗剂,可抑制丙型肝炎病毒 (HCV) 的复制,其EC50值为 14 nM。
生物活性

ACH-806 is anNS4Aantagonist which can inhibit Hepatitis C Virus (HCV) replication with anEC50of 14 nM.

IC50& Target

NS4A[1]
EC50: 14 nM (HCV)[1]

体外研究
(In Vitro)

ACH-806 is an NS4A antagonist which can inhibit Hepatitis C Virus (HCV) replication with an EC50of 14 nM. ACH-806 treatment results in significant reductions of both NS3 and NS4A in the transfected cells. This finding is reminiscent of ACH-806-treated replicon cells in which the amounts of NS3 and NS4A are also both decreased. The total amount of NS3 in the ACH-806-treated sample is reduced by ~6-fold (100/16) and causes a reduction of NS4A-bound NS3 ~29-fold (261/9). The levels of labeled NS3 and NS4A immunoprecipitated by anti-NS3 antibody are apparently reduced after the treatment of ACH-806. ACH-806 also induces significant decreases of NS3 and NS4A and promotes p14 formation in the parental replicon cells but not in the ACH-806-resistant replicon cells[1].

分子量

411.44

Formula

C19H20F3N3O2S

CAS 号

870142-71-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.