Vitexilactone

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Vitexilactone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

61263-49-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Vitexilactone 是一种二萜类化合物，可从黄荆 (Vitex negundoL.) 的叶片中分离出来。Vitexilactone 对E. coli具有抑菌活性。Vitexilactone 诱导癌细胞凋亡并抑制细胞周期。Vitexilactone 可用于癌症的研究。

生物活性

Vitexilactone is a diterpenoid that can be isolated from the leaves ofVitex negundoL. Vitexilactone shows antimicrobial activity towardsE. coli. Vitexilactone induces cellapoptosisand inhibits cell cycle ofcancercells. Vitexilactone can be used for the research ofcancer^[1]^[2].

体外研究
(In Vitro)

Vitexilactone 对E. coli表现出显著的抗菌活性，MIC 值 >90 μg/mL^[1]。
Vitexilactone (0-100 μg/mL; 17-24 h) 抑制哺乳动物癌细胞的增殖^[2]。
Vitexilactone (25-100 μg/mL; 17 h) 高浓度时诱导细胞凋亡，低浓度时抑制细胞周期 G0/G1期，在 tsFT210 和 K562 细胞中^[2]。

Cell Proliferation Assay^[2]

Cell Line:	tsFT210 and K562 cells lines
Concentration:	0-100 μg/mL
Incubation Time:	17-24 hours
Result:	Inhibited cell proliferation of mammalian cancer cells with IC₅₀values of 86.9 and 57.9 μg/mL for tsFT210 and K562 cells, respectively.

Apoptosis Analysis^[2]

Cell Line:	tsFT210 and K562 cell lines
Concentration:	25-100 μg/mL
Incubation Time:	17 hours
Result:	Induced cell apoptosis of tsFT210 with a MIC value of 25 μg/mL.

Cell Cycle Analysis^[2]

Cell Line:	tsFT210 and K562 cell lines
Concentration:	25-100 μg/mL
Incubation Time:	17 hours
Result:	Inhibited G0/G1 phase of cell cycle with the dose ranges of 50-6.25 μg/mL in tsFT210 cells.

分子量

378.50

Formula

C₂₂H₃₄O₅

CAS 号

61263-49-8

结构分类

Terpenoids
Diterpenoids

来源

Plants
Verbenaceae
Vitex negundoLinn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.