CP-67015, a quinoloneantibiotic, is a potenttopoisomeraseIIinhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects^[1].

CP-67015 (10-100 μg/mL; 12-36 h) produces a drastic increase in chromosome damage in human lymphocytes and in CHO cells^[1].
CP-67015 inhibits supercoiling activity of prokaryotic DNA gyrase, with 100% inhibition at the concentration of 4.0 μg/mL^[1].

CP-67015 (a single dose 1000 mg/kg or 500 mg/kg/day for 5 days; i.p.) induces chromosome damage in male CD-1 mice in mouse bone marrow cells^[1].

330.29

C₁₇H₁₂F₂N₂O₃

100325-51-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.