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Erythromycin stearate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Erythromycin stearate图片
CAS NO:643-22-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
红霉素硬脂酸盐
产品介绍
Erythromycin stearate 是由放线菌产生的大环内酯类抗生素 (antibiotic),具有广泛的抗菌活性。Erythromycin stearate 通过结合细菌的 50S 核糖体亚基而起作用,并通过阻断转肽和/或易位反应来抑制 RNA 依赖性蛋白 (RNA-dependent protein synthesis) 的合成,而不会影响核酸的合成。Erythromycin stearate 在不同领域的研究中显示出抗肿瘤特性和保护神经的作用。
生物活性

Erythromycin stearate is amacrolideantibioticproduced byactinomycete Streptomyceserythreus with a broad spectrum of antimicrobial activity. Erythromycin stearate binds tobacterial50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin stearate also exhibits antitumor and neuroprotective effect in different fields of research[3][4].

IC50& Target

Macrolide

 

体外研究
(In Vitro)

Erythromycin stearate inhibits growth ofP. falciparumwith IC50and IC90values of 58.2 μM and 104.0 μM, respectively[1].
Erythromycin stearate (10 μM, 100 μM; 24 h, 72 h) shows antioxidant and anti-inflammatory effects and suppresses the accumulation of 4-HNE (p<0.01) and 8-OHdG (p<0.01), reduces Iba-1 (p<0.01) and TNF-α (p<0.01) expression significantly[4].

Cell Viability Assay[4]

Cell Line:Embryos primary cortical neuron (from the cerebral cortices of 17-day-old Sprague-Dawley rat)
Concentration:10, 100 μM
Incubation Time:24, 72 hours
Result:Improved the viability of cultured neuronal cells in vitro after 3 hours oxygen-glucose deprivation (OGD).
体内研究
(In Vivo)

Erythromycin stearate (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth and prolong the survival time of mice from dose of 5 mg/kg in mice[3].
Erythromycin stearate (gastric intubation; 5 mg/kg) protects mice alive even at 120 days after inoculation, but shortens mean survival time in tumor-bearing mice by 4-5 days with dose of 50 mg/kg[3].
Erythromycin stearate (i.h.; single injection; 50 mg/kg) has a protective effect on the rat model with cerebral ischemia reperfusion-injury[4].

Animal Model:Female ddY mice (6-week-old) with EAC cells or CDF mice (6-week-old) with P388 cells[3]
Dosage:0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg
Administration:Gastric intubation; 30-120 days
Result:Decreased tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortened the MST in tumorbearing mice.
Animal Model:Male Sprague-Dawley rats (8-week-old, 250-300 g)[4]
Dosage:50 mg/kg
Administration:Subcutaneous single injection
Result:Reduced infarct volume and edema volume, improved neurological deficit.
Clinical Trial
分子量

1018.40

Formula

C55H103NO15

CAS 号

643-22-1

中文名称

红霉素硬脂酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.