Antofloxacin is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potentantibacterialactivities. Antofloxacin shows superiorantibacterialactivity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin is a weak, reversible inhibitor ofCYP1A2for the treatment of infections caused by a diverse group ofbacterialspecies^[1][2][3].

Antofloxacin (2.5~160 mg/kg; s.c.; 24 hours) penetration ratio ranges from 1.22 to 1.54 for the total drug concentrations and is independent of the dose levels^[3]. Antofloxacin increases the plasma theophylline concentration, partly by acting as a mechanism based inhibitor of CYP1A2. Antofloxacin inhibits the formation of the three metabolites of theophylline was time-, concentration- and NADPH-dependent, which is characteristic of mechanism-based inhibition^[2].

376.38

C₁₈H₂₁FN₄O₄

119354-43-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.