Cefatrizine

立即咨询

Cefatrizine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

51627-14-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

BL-S-640
SK&F 60771

产品介绍

Cefatrizine (BL-S-640) 是一种口服有效的广谱头孢菌素类抗生素。Cefatrizine 也是一种eEF2K抑制剂，在人乳腺癌细胞中具有抗增殖活性，可诱导 ER 应激，导致细胞死亡。Cefatrizine 可用于癌症和细菌感染的研究。

生物活性

Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporinantibiotic. Cefatrizine is also aeEF2Kinhibitor, with anti-proliferative activity in human breastcancercells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies ofcancerandbacterialinfection^[1]^[2].

IC₅₀& Target

β-lactam

体外研究
(In Vitro)

Cefatrizine (0-100 μM; 24 h) causes a remarkable anti-proliferative effect on MCF-7 and MDA-MB-436 cell growth in a dose-dependent manner^[1].
Cefatrizine (30 μM; 12 h) induces ER stress in breast cancer cells^[1].
Cefatrizine (12, 24, 36 h) increases level of CHOP (marker of ER stress induced apoptosis) and promotes expressions of core proteins in eEF2K-modulated ER stress pathways (Bip, p-PERK, XBP-1S and p-JNK) in MCF-7 and MDA-MB-436 cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	MCF-7, MDA-MB-436 cells
Concentration:	0-100 μM
Incubation Time:	24 h
Result:	Led to a remarkable anti-proliferative effect on cells and resulted in almost 50% inhibition in the MCF-7 and MDA-MB-436 cells when at 33 μM and 29 μM.

Cell Viability Assay^[1]

Cell Line:	MCF-7, MDA-MB-436 cells
Concentration:	30 μM
Incubation Time:	12 h
Result:	Led to massive cytoplasmic vacuolization.

体内研究
(In Vivo)

Cefatrizine (BL-S-640) (0.2, 1, 5, 25 mg/kg; p.o.; 4 times daily for 3 days) reduces the number of infecting organisms in the bladder and the kidneys inP. mirabilisintracystically infected model^[2].

Animal Model:	MaleSwiss-Webster mice (19-21 g;P. mirabilisintracystically infected model)^[2].
Dosage:	0.2, 1, 5, 25 mg/kg
Administration:	Oral administration; 4 times daily for 3 days.
Result:	Reduced the number of infecting organisms to less than 1,000 in the bladder when 1 mg/kg, and in the kidneys when 0.2 mg/kg.

分子量

462.50

Formula

C₁₈H₁₈N₆O₅S₂

CAS 号

51627-14-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:

H₂O : 250 mg/mL(540.54 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.1622 mL	10.8108 mL	21.6216 mL
5 mM	0.4324 mL	2.1622 mL	4.3243 mL
10 mM	0.2162 mL	1.0811 mL	2.1622 mL