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Antofloxacin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Antofloxacin hydrochloride图片
CAS NO:873888-67-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Antofloxacin hydrochloride 是一种耐受性好、口服有效、广谱的 8- 氨基氟喹诺酮类药物,具有强antibacterial活性。与左氧氟沙星相比,Antofloxacin hydrochloride 对 gyrA 突变阳性的幽门螺杆菌表现出更强的antibacterial活性,特别是对 Asn87 突变株。Antofloxacin hydrochloride 是一种弱的、可逆的CYP1A2抑制剂,用于治疗由多种细菌引起的感染。
生物活性

Antofloxacin hydrochloride is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potentantibacterialactivities. Antofloxacin hydrochloride shows superiorantibacterialactivity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin hydrochloride is a weak, reversible inhibitor ofCYP1A2for the treatment of infections caused by a diverse group ofbacterialspecies[1][2][3].

IC50& Target

Quinolone

 

体内研究
(In Vivo)

Antofloxacin (2.5~160 mg/kg; s.c.; 24 hours) penetration ratio ranges from 1.22 to 1.54 for the total drug concentrations and is independent of the dose levels[3]. Antofloxacin increases the plasma theophylline concentration, partly by acting as a mechanism based inhibitor of CYP1A2. Antofloxacin inhibits the formation of the three metabolites of theophylline was time-, concentration- and NADPH-dependent, which is characteristic of mechanism-based inhibition[2].

Animal Model:Mice (Pharmacokinetic Analysis)[3]
Dosage:2.5~160 mg/kg
Administration:S.c.; 24 hours
Result:Penetration ratio ranged from 1.22 to 1.54 for the total drug concentrations and was independent of the dose levels.
分子量

412.84

Formula

C18H22ClFN4O4

CAS 号

873888-67-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.