Sitafloxacin (DU6859a) monohydrate is a potent, orally active fluoroquinoloneantibiotic. Sitafloxacin monohydrate shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin monohydrate can be used for the research of respiratory tractinfectionand urinary tractinfection^[1][2].

Sitafloxacin (DU6859a) monohydrate shows antibacterial activities with MIC of 0.03, 0.12, 0.06 mg/L for wild-type ATCC 49619,gyrAmutant SP39,parCmutant 1026523streptococcus pneumoniaestran, respectively^[1].
Sitafloxacin (DU6859a) monohydrate shows antibacterial activities for quinolone-susceptible strains ofstreptococcus pneumoniaewith MIC of 0.03, 0.03 mg/L for EG 00093 and EG 00218 strain, respectively^[1].
Sitafloxacin (DU6859a) monohydrate shows inhibition for DNA gyrase and topoisomerase IV (TopoIV) with >IC₅₀s of 4.38, 3.12 mg/L, respectively^[1].

Sitafloxacin (DU6859a; 12.5-100 mg/kg; i.g.; daily for 4 weeks; BALB/c female mice) monohydrate has antibacterial activity.M. ulceranscells could be isolated from the inoculated footpads and there was no evidence of footpad swelling^[2].

427.83

C₁₉H₂₀ClF₂N₃O₄

163253-37-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.