Cefotiam

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Cefotiam

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

61622-34-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

SCE-963

产品介绍

Cefotiam (SCE-963) 是肠外头孢菌素类抗生素。Cefotiam 对革兰氏阳性菌和革兰氏阴性菌具有广谱活性。

生物活性

Cefotiam (SCE-963) is a parenteral cephalosporinantibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria^[1]^[2].

IC₅₀& Target

β-lactam

体外研究
(In Vitro)

Cefotiam (SCE-963; 0-6.25μg/mL; 8 h) has antibacterial activity with a MIC value of 1.56 μg/mL forP. mirabilisIFO 3849^[1].
Cefotiam (0-6.25μg/mL; 8 h) has highly active against bothStaph. aureus(27 strains, MIC values of 0.5-1 μg/mL) andStaph. albus(8 strains, MICs 0.25-0.5 μg/mL). All 29 strains ofhaemolytic streptococci, 9 strains ofpneumococciand 6 strains ofStreptococcus viridanswith the MIC values of in the range 0.06-4 μg/mL^[2].

体内研究
(In Vivo)

Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) can cure urinary tract infection withP. mirabilisin mice to reduce or complete eradicate bacteria in the bladder walls and kidneys^[1].

Animal Model:	Female CF1/b mice withP. mirabilisxenograft^[1]
Dosage:	12.5, 25, 50, 100, 200, 400 and 800 mg/kg
Administration:	Subcutaneous injection; twice a day, for 5 days
Result:	Reduced or complete eradicated bacteria in the bladder walls and kidneys of mice sacrificed the day after treatment was terminated.

Clinical Trial

分子量

525.63

Formula

C₁₈H₂₃N₉O₄S₃

CAS 号

61622-34-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.