Zabofloxacin hydrochloride (DW-224a) is a potent and seletive inhibitor of thebacterialtype II and IV topoisomerases. Zabofloxacin hydrochloride has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin hydrochloride is a novel fluoronaphthyridonequinolonethat is considered as an alternativeantibioticfor treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)^[1].

Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive S. pneumoniae (minimum inhibitory concentration, MIC₉₀: 0.03 mg/L) and penicillin-resistant S. pneumoniae (MIC₉₀: 0.03 mg/L). Against quinolone-resistant S. pneumoniae, zabofloxacin (MIC₉₀: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin^[1].

437.85

Solid

C₁₉H₂₁ClFN₅O₄

623574-00-5

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 6.67 mg/mL(15.23 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。