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Doxycycline calcium
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Doxycycline calcium图片
CAS NO:94088-85-4
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Doxycycline calcium 是一种具有口服活性的四环素抗生素，是广谱的金属蛋白酶 (MMP) 抑制剂，具有抗菌活性和抗癌细胞增殖活性。
生物活性

Doxycycline calcium, anantibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline calcium shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5].

IC50& Target

Tetracycline

 

体外研究
(In Vitro)

Doxycycline calcium (0.01-10 μg/mL, 4 d) affects growth of glioma cells only under high concentrations[2].
Doxycycline calcium (0.01-10 μg/mL, 24 h) decreases MT-CO1 protein content with concentrations of 1 μg/mL and higher in SVG cells[2].
Doxycycline calcium (100 ng/mL, 1 μg/mL; 24 h) reduces proliferation of human cell lines[4].
Doxycycline calcium (0-250 μM, 72 h) inhibits cell viability of breast cancer cells[5].

Cell Viability Assay[2]

Cell Line:LNT-229, G55, and U343 glioma cells
Concentration:0.01, 0.1, 1 or 10 μg/mL
Incubation Time:4 days
Result:Affected growth of glioma cells only under high concentration (10 μg/mL).

Cell Viability Assay[2]

Cell Line:SVG cells
Concentration:0.01, 0.1, 1 or 10 μg/mL
Incubation Time:24 hours
Result:Decreaseed MT-CO1 protein content with concentrations of 1 μg/mL and higher.

Cell Proliferation Assay[4]

Cell Line:MCF 12A, 293T cells
Concentration:100 ng/mL, 1 μg/mL
Incubation Time:96 hours
Result:Caused reduced proliferation of MCF 12A and 293T cells at 1 μg/mL.

Cell Viability Assay[5]

Cell Line:MCF-7, MDA-MB-468 cells
Concentration:0-250 μM
Incubation Time:72 hours
Result:Inhibited breast cancer cells in a dose-dependent manner with IC50values for MCF-7 and MDA-MB-468 of 11.39 μM and 7.13 μM respectively.
体内研究
(In Vivo)

Doxycycline calcium (oral gavage; 200 or 800 mg/kg; once daily; 3 months) reduces MMP-9 activity in untreated HT mice in a dose-dependent manner[3].

Animal Model:6-month-old female Heterozygous Col3a1-deficient (HT) mice[3]
Dosage:200 or 800 mg/kg
Administration:Oral gavage; 200 or 800 mg/kg; once daily; 3 months
Result:Reduced MMP-9 activity in a dose-dependent manner.
Clinical Trial
分子量

524.59

Formula

C22H24Ca2N2O8

CAS 号

94088-85-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.