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Chitin synthase inhibitor 1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Chitin synthase inhibitor 1图片
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Chitin synthase inhibitor 1 是一种有效的选择性几丁质合酶 (CHS) 抑制剂 (IC50=0.12 mM)。Chitin synthase inhibitor 1 对耐药真菌变体具有强效抗真菌活性。
生物活性

Chitin synthase inhibitor 1 is a potent and selectivechitin synthase (CHS)inhibitor (IC50=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants[1].

IC50& Target

IC50: 0.12 mM (CHS)[1]

体外研究
(In Vitro)

Chitin synthase inhibitor 1 (compound 5a) shows broad-spectrum antifungal activity (MIC=4 μg/mL inCandidaalbicans (C. albicans)ATCC 76615 andAspergillus fumigatus (A. fumigatus)GIMCC 3.19; MIC=8 μg/mL inAspergillus flavus (A. flavus)ATCC 16870 andCrytococcusneoformans (C. neoformans)ATCC 32719)[1].
Chitin synthase inhibitor 1 shows antifungal activity against drug-resistant fungi variants (MIC=32 μg/mL in FluconazoleresistantC.albicansATCC 76615R, Fluconazole-resistantA.fumigatusGIMCC 3.19R, and Fluconazole-resistantC. neoformansATCC 32719R, MicafunginresistantC.albicansATCC 76615R’; MIC=16 μg/mL in Fluconazole-resistantA.flavusATCC 16870R)[1].

分子量

409.87

Formula

C22H20ClN3O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.