Secnidazole (RP-14539) hemihydrate is an orally active azoleantibioticand a imidazole mitigator ofSerratia marcescensvirulence. Secnidazole hemihydrate, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation ofPseudomonas aeruginosapathogenesis. Secnidazole hemihydrate has antimicrobial activity against many anaerobic Gram-negative and Gram-positivebacterialspecies in vitro. Secnidazole hemihydrate can be used for the research of various diseases, such as amoebiasis and giardiasis, andbacterialvaginitis^[1][2][3].

Secnidazole (RP-14539) hemihydrate (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC₅₀values of 3873 μM and 3722 μM, respectively^[2].
Secnidazole hemihydrate (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition^[2].
Secnidazole hemihydrate (0-5000 μM; 5 or 10 min) has an apparent IC₅₀value of 503 μM for direct inhibition of human ALDH2^[2].
Secnidazole hemihydrate (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6^[2].
Secnidazole hemihydrate (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibitsS.marcescensgrowth with a MIC₅₀value of 10 mg/mL^[3].

Secnidazole (RP-14539) hemihydrate (100 μL; ip.; for 5 days) has protective activity againstS.marcescenspathogenesis and can diminish its pathogenesis in mice^[3].

194.19

C₇H₁₃N₃O₄

227622-73-3

塞克硝唑半水合物

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.