Secnidazole (RP-14539) is an orally active azoleantibioticand a imidazole mitigator ofSerratia marcescensvirulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation ofPseudomonas aeruginosapathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positivebacterialspecies in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, andbacterialvaginitis^[1][2][3].

Secnidazole (RP-14539) (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC₅₀values of 3873 μM and 3722 μM, respectively^[2].
Secnidazole (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition^[2].
Secnidazole (0-5000 μM; 5 or 10 min) has an apparent IC₅₀value of 503 μM for direct inhibition of human ALDH2^[2].
Secnidazole (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6^[2].
Secnidazole (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibitsS.marcescensgrowth with a MIC₅₀value of 10 mg/mL^[3].

Secnidazole (100 μL; ip.; for 5 days) has protective activity againstS.marcescenspathogenesis and can diminish its pathogenesis in mice^[3].

185.18

Solid

C₇H₁₁N₃O₃

3366-95-8

塞克硝唑

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 30 mg/mL(162.00 mM)

H₂O : 25 mg/mL(135.00 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 50 mg/mL (270.01 mM); Clear solution; Need ultrasonic