Ertapenem sodium

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Ertapenem sodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

153773-82-1

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

厄他培南钠
L-749345
MK-826

产品介绍

Ertapenem sodium (L-749345) 是一种广谱的长效 β-内酰胺。Ertapenem sodium 对多种厌氧菌具有广谱抗菌活性，其MIC值为 0.12 μg/mL。Ertapenem sodium 可用于皮肤、肺、胃、骨盆和泌尿道的细菌感染相关的研究。

生物活性

Ertapenem sodium (L-749345) is a broad spectrum and long acting β-lactamantibiotic. Ertapenem sodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a modeMICof 0.12 μg/mL. Ertapenem sodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract^[1]^[2].

IC₅₀& Target

β-lactam

体外研究
(In Vitro)

Ertapenem sodium (0-100 μg/mL approximately, 48 h) is active against 99.1% of all anaerobes with a mode MIC of 0.12 μg/mL and MIC₉₀of 1 μg/mL, and MIC’s ≥8 μg/mL for B.fragilis and B.vulgatus species, respectively^[1].

Cell Viability Assay^[1]

Cell Line:	B. fragilis(ATCC 25285),B. thetaiotaomicron(ATCC 29741), andEubacterium lentum(ATCC 43055)
Concentration:	0-100 μg/mL approximately
Incubation Time:	48 h
Result:	Inhibited 99.1% of all isolate with a mode MIC of 0.12 μg/mL and MIC₉₀of 1 μg/mL, and 98.8% of the isolates were susceptible among the B. fragilis group.

体内研究
(In Vivo)

Ertapenem sodium (Subcutaneous injection, 0-10 mg/kg, 0-120 h after infection,S. aureusthigh tissue infection model) shows >3 log₁₀CFU reduction of organism at 10 mg/kg, and maintains the activity with 3.3 and 4.4 log₁₀CFU eliminated at 2 mg/kg^[2].
Ertapenem sodium (Subcutaneous injection, 4h after infection, systemic infection model) is active against all gram-positive organisms, and is also active against gram-negative organisms tested with ED₅₀s of<0.25 mg/kg/dose^[2].

Animal Model:	S. aureusthigh tissue infection model (DBA/2 mice)^[2]
Dosage:	0.5,1, 2, 5, 10 mg/kg (given at 2, 6, 10, 24, 48, 72, 96, 120 h)
Administration:	Subcutaneous injection (0.5 mL after infection)
Result:	Displayed >3 log₁₀CFU reduction of organism compared to non-antibiotic-treated controls at 10 mg/kg. Maintained the activity with 3.3 and 4.4 log₁₀CFU eliminated at 2 mg/kg.

Animal Model:	Systemic infection model (DBA/2 female mice, viral antibody-free CD-1 female mice)^[2]
Dosage:	0-3 mg/kg approximately
Administration:	Subcutaneous injection (0.5 mL, begin immediately and 4 h after infection)
Result:	Showed activity against all gram-positive organisms, and also ram-negative organisms tested with ED₅₀s of<0.25 mg/kg/dose.

Animal Model:	CD-1 mice, rats^[2]
Dosage:	10 mg/kg approximately
Administration:	Intraperitoneal injection (pharmacokinetic assay)
Result:	Exhibited an AUC_0-∞ranging from 1.8-21.82 μgohr/mL in tissue in mice following a 10-mg/kg i.p. dose. Exhibited slow clearance rate with a t_1/2βof 3.2 h, Clp of 0.47 mL/min/kg, AUC_0-8of 284.15 μgohr/mL.

Clinical Trial

分子量

497.50

性状

Solid

Formula

C₂₂H₂₄N₃NaO₇S

CAS 号

153773-82-1

中文名称

厄他培南钠；尔他培南钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 50 mg/mL(100.50 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.0101 mL	10.0503 mL	20.1005 mL
5 mM	0.4020 mL	2.0101 mL	4.0201 mL
10 mM	0.2010 mL	1.0050 mL	2.0101 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (201.01 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。