Sarecycline hydrochloride is a narrow-spectrum tetracycline-classantibiotic. Sarecycline hydrochloride possesses anti-inflammatory properties and potent activity against Gram-positive bacteria, including activity against multiple strains ofCutibacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome^[1][2][3].

Sarecycline inhibits 55 clinical isolates ofC. acnes, and the MIC values for Sarecycline ranged from 0.5 to 16 μg/ml; the MIC₅₀was 0.5 μg/ml, and the MIC₉₀was 4 μg/ml. Sarecycline, exhibits activity against the macrolide-resistant organisms^[1].
Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria^[2].

Sarecycline hydrochloride (0.33-9 mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model^[1].

523.96

Solid

C₂₄H₃₀ClN₃O₈

1035979-44-2

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

DMSO : 100 mg/mL(190.85 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。