Dalbavancin

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Dalbavancin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

171500-79-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

达巴万星
MDL-63397
BI-397

产品介绍

Dalbavancin (MDL-63397) 是一种半合成的脂糖肽抗生素，对革兰氏阳性细菌具有有效的杀菌活性。Dalbavancin 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC₉₀分别为 0.06 μg/mL 和 0.25 μg/mL。

生物活性

Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptideantibioticwith potent bactericidal activity againstGram-positive bacteria. Dalbavancin inhibitsStaphylococcus aureusandBacillus anthraciswith MIC₉₀s of 0.06 μg/mL and 0.25 μg/mL, respectively^[1]^[2].

IC₅₀& Target

Glycopeptide

体外研究
(In Vitro)

Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens includingS. aureus(MRSA), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA andβ-hemolytic streptococci, organisms against which it has shown greater potency than existing glycopeptide therapeutic agents^[1]^[2].

体内研究
(In Vivo)

Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens^[1].

Animal Model:	Female BALB/c mice (6-8 weeks) challenged with Ames strain ofB. anthracis^[1]
Dosage:	15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration:	Intraperitoneal injection; every 36 h or 72 h; for 14 days
Result:	The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.

Clinical Trial

分子量

1816.69

Formula

C₈₈H₁₀₀Cl₂N₁₀O₂₈

CAS 号

171500-79-1

中文名称

达巴万星；道古霉素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.