Cefilavancin

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Cefilavancin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1393900-12-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

TD-1792

产品介绍

Cefilavancin (TD-1792) 是一种有效的多价糖肽-头孢类异二聚体抗生素 (antibiotic)，有效抵抗革兰氏阳性菌 (bacteria)。Cefilavancin 已被用于研究皮肤感染。

生物活性

Cefilavancin (TD-1792) is a potent multivalent glycopeptide-cephalosporin heterodimerantibioticwith effective activity against Gram-positivebacteria. Cefilavancin has been used to research skin infections^[1]^[2]^[3].

IC₅₀& Target

Glycopeptide

体外研究
(In Vitro)

Cefilavancin (TD-1792) has highly active againstMethicillin-susceptibleStaphylococcus aureus(MIC₉₀= 15 ng/mL),Methicillin-resistantStaphylococcus aureus, and heterogeneousVancomycin-intermediateStaphylococcus aureus(MIC₉₀= 30 ng/mL)^[1].

体内研究
(In Vivo)

Cefilavancin (0.03-10 mg/kg; s.c.) produces a dose-dependent reduction of thigh bacterial burden in infected mice^[3].

Animal Model:	Female NSA mice (18-30 g; neutropenia induced by administering cyclophosphamide, then injected bacteria into the posterior thigh)^[3]
Dosage:	0.03-10 mg/kg
Administration:	s.c.; single dosage (every 24 h) or two (every 12 h), three (every 8 h), or four (every 6 h) divided doses
Result:	Produced a maximal of approximately 1- to 2-log₁₀kill against MRSA ATCC 33591, MSSA ATCC 29213, and MRSE MED 820 and ≥3-log₁₀kill against VISA HIP 5836, MSSE SU03, PSSP MED35, PSSP MED1119, andStreptococcus pyogenesMED 2040 strains.

Clinical Trial

分子量

1983.26

Formula

C₈₇H₉₅Cl₃N₁₆O₂₈S₂

CAS 号

1393900-12-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.