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m-PEG7-Amine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
m-PEG7-Amine图片
CAS NO:170572-38-0
包装与价格:
包装价格(元)
100mg电议
250mg电议

产品介绍
m-PEG7-Amine 是一种 PROTAC 连接桥,属于 PEG 类。m-PEG7-Amine 可用于合成一系列 PROTAC 分子。m-PEG7-Amine 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。
Cas No.170572-38-0
分子式C15H33NO7
分子量339.43
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG7-Amine is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs. m-PEG7-Amine is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.