Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrumaminoglycosideantibioticwith amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site ofbacterial30S ribosomes. Paromomycin sulfate can be used for the research ofbacterialand parasitic infections^[1][2][3].

Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellularC. parvumforms by 99.5% in HCT-8 cells^[2].

Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected withC. parvumand only 10% of focal inflammation at 200 mg/kg^[1].

713.71

Solid

C₂₃H₄₇N₅O₁₈S

1263-89-4

硫酸新霉素杂质E

• Antibiotics
• Other Antibiotics

Streptomyces rimosus NRRL 2455

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 100 mg/mL(140.11 mM;ultrasonic and warming and heat to 80℃)

Ethanol : 1 mg/mL(1.40 mM;Need ultrasonic)

DMSO : 1 mg/mL(1.40 mM;ultrasonic and warming and heat to 80℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 100 mg/mL (140.11 mM); Clear solution; Need ultrasonic