Capreomycin

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Capreomycin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

11003-38-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Capreomycin 是一种大环肽类抗生素 (antibiotic)。Capreomycin 可用于抗多耐药性结核分枝杆菌的研究。Capreomycin 可抑制分枝杆菌核糖体转译中苯丙氨酸的合成。

生物活性

Capreomycin is a macrocyclic peptideantibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation^[1]^[2]

IC₅₀& Target

Aminoglycoside

体内研究
(In Vivo)

Capreomycin (1.4, 7.2, and 14.5 mg/kg for inhale; 20 mg/kg for i.m.; 4 weeks) decreases the wet lung weight and lowers bacterial burden in the lungs of infected guinea pigs^[2].

Animal Model:	Male guinea pigs [836 ± 162.3 g; infected via the respiratory route with nebulized suspensions 2 × 10⁵CFU/mL ofMycobacterium tuberculosis(strain H37Rv)]^[2]
Dosage:	1.4, 7.2, and 14.5 mg/kg for inhale; 20 mg/kg for i.m.
Administration:	Inhaling or i.m.; 4 weeks
Result:	Significantly decreased the wet lung weight at 14.5 mg/kg, and smaller than receiving 1.4 mg/kg group and controls. Significantly lowered bacterial burden in the lungs (3.52 ± 0.20 CFU/mL; P< 0.05) at 14.5 mg/kg than controls (4.58 ± 0.20 CFU/mL) and at 1.4 and 7.2 mg/kg (4.02 ± 0.32 and 4.01 ± 0.29 CFU/mL, respectively).

Clinical Trial

CAS 号

11003-38-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.