| CAS NO: | 71678-03-0 |
| 包装: | 100 μg |
| 生物活性 | Ilimaquinone, a marinespongemetabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus[1]. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects[2]. | |||||||||
| 体外研究 (In Vitro) | Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM ; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI50s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively[1]. Cell Viability Assay[1]
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| 体内研究 (In Vivo) | Ilimaquinone exhibits terminal elimination half-lives (T1/2=1.2±0.3 h) due to high plasma clearance (2.95±0.53 L/h/kg) following oral administration (10 mg/kg) in male Sprague-Dawley rats[2]. | |||||||||
| 分子量 | 358.47 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C22H30O4 | |||||||||
| CAS 号 | 71678-03-0 | |||||||||
| 结构分类 |
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| 来源 | marine sponge Halichondria sp. | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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