Fenbendazole-d3 is a deuterium labeled Fenbendazole. Fenbendazole-d3 is aHIF-1αagonist and activates the HIF-1α-relatedGLUT1pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53^[1][2][3][4].

芬苯达唑d3 (20 μM; 48 小时) 逆转了 miR-143-5p 对增殖、集落形成能力和迁移的抑制作用^[1]。
芬苯达唑d3 (20 μM; 48 小时) 可以提高 HIF-1α 和 GLUT1 的蛋白质表达水平^[1]。

302.37

Solid

C₁₅H₁₀D₃N₃O₂S

1228182-47-5

芬苯达唑 d3

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

DMSO : 5 mg/mL(16.54 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。