Pregnenolone-d4-1 (3β-Hydroxy-5-pregnen-20-one-d4-1) is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor ofcannabinoidCB1receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by theCB1receptors. Pregnenolone can protect the brain from cannabis intoxication^[1][2]. Pregnenolone is also aTRPM3 channelactivator, and also can weakly activateTRPM1 channels^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

320.50

Solid

C₂₁H₂₈D₄O₂

61574-54-7

Room temperature in continental US; may vary elsewhere.

DMSO : 31.25 mg/mL(97.50 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。