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Eslicarbazepine acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Eslicarbazepine acetate图片
CAS NO:236395-14-5
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议

产品介绍
Eslicarbazepine acetate (BIA 2-093) 是一种抗癫痫药物,是 β-分泌酶和电压门控钠通道的双重 a 双重抑制剂。
Cas No.236395-14-5
别名艾司利卡西平醋酸酯,BIA 2-093
化学名(S)-10-acetoxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carbimidic acid
Canonical SMILESCC(O[C@@]1([H])CC2=CC=CC=C2N(C(O)=N)C3=CC=CC=C31)=O
分子式C17H16N2O3
分子量296.32
溶解度≥ 14.85mg/mL in DMSO
储存条件Store at 2-8℃, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Eslicarbazepine acetate, an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.

Eslicarbazepine acetate is an antiepileptic drug. It is a prodrug which is activated to eslicarbazepine (S-licarbazepine), an active metabolite of oxcarbazepine. Eslicarbazepine acetate is a prodrug for (S)-(+)-licarbazepine, the major active metabolite of oxcarbazepine. Its mechanism of action is therefore identical to that of oxcarbazepine. Eslicarbazepine acetate may not produce as high peak levels of (S)-(+)-licarbazepine immediately after dosing as does oxcarbazepine which could theoretically improve tolerability[1].

References:
[1]. Sibhghatulla Shaikh, et al. Aptiom (Eslicarbazepine Acetate) as a Dual Inhibitor of β-Secretase and Voltage-Gated Sodium Channel: Advancement in Alzheimer's Disease-Epilepsy Linkage via an Enzoinformatics Study. CNS & Neurological Disorders Drug Targets Volume 13 , Issue 7 , 2014.