| CAS NO: | 6729-55-1 |
| 包装: | 50mg |
| 市场价: | 1061元 |
| Cas No. | 6729-55-1 |
| 别名 | Γ-D-谷氨酰基甘氨酸,γDGG; γ-D-Glutamylglycine |
| 化学名 | (S)-2-amino-5-((carboxymethyl)amino)-5-oxopentanoic acid |
| Canonical SMILES | O=C(CC[C@@H](C(O)=O)N)NCC(O)=O |
| 分子式 | C7H12N2O5 |
| 分子量 | 204.18 |
| 溶解度 | Soluble to 100 mM in 1eq. NaOH and to 100 mM in sterile water |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | gamma-DGG is a competitive AMPA receptor blocker. gamma-DGG (γ-DGG), a competitive AMPA receptor blocker that blocks less at higher glutamate concentration. At 200-400 μM, gamma-DGG in the bath reduces the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses), and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left[1]. gamma-DGG (γ-DGG) is the most effective antagonist of the excitatory post-synaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p. Quantal analysis shows that the reduction in the e.p.s.p. paralleled the decrease in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG[2]. References: |
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