| CAS NO: | 6159-05-3 |
| 包装: | 100mg |
| 市场价: | 450元 |
| Cas No. | 6159-05-3 |
| 别名 | 二溴化-1,1ˊ-二庚基-4,4ˊ-联吡啶鎓,Diheptylviologen dibromide |
| 化学名 | 1,1'-diheptyl-[4,4'-bipyridine]-1,1'-diium bromide |
| Canonical SMILES | CCCCCCC[N+](C=C1)=CC=C1C2=CC=[N+](C=C2)CCCCCCC.[Br-].[Br-] |
| 分子式 | C24H38Br2N2 |
| 分子量 | 514.39 |
| 溶解度 | Soluble to 100 mM in sterile water |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DHBP dibromide is an inhibitor for calcium release and a muscle relaxant. DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor[1]. References: |
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