ATP-13C10,15N5 (Adenosine 5'-triphosphate-13C10,15N5) disodium is a 13C-labeled and 15N-labeledATP(HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation^[1][2][3][4].

ATP-13C10,15N5 (Adenosine 5'-triphosphate-13C10,15N5; 5 mM; 1 hour) disodium co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs^[3].
ATP-13C10,15N5 (2 mM; 0.5-24 hours) disodium induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner^[4].
ATP-13C10,15N5 disodium promotes neutrophil chemotaxis in vitro^[4].

ATP-13C10,15N5 (Adenosine 5'-triphosphate-13C10,15N5; 50 mg/kg; i.p.) disodium protects mice against bacterial infection in vivo^[4].
ATP-13C10,15N5 disodium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo^[4].

568.05

Liquid

¹³C₁₀H₁₆¹⁵N₅Na₂O₁₃P₃

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years