CDK9-PROTAC (PROTAC CDK9 Degrader-1) is a novel, potent and selective CDK9 (Cyclin-dependent kinase 9) degrader. CDK9-PROTAC is a heterobifunctional small molecule proteolysis targeting chimera (PROTAC) capable of cereblon (CRBN) mediated proteasomal degradation of CDK9. CDK9 is a member of the cyclin-dependent protein kinase (CDK) family that is involved in transcriptional elongation of several target genes. CDK9 is ubiquitously expressed and has been shown to contribute to a variety of malignancies such as pancreatic, prostate and breast cancers. In HCT116 cells, CDK9-PROTAC selectively degrades CDK9 while sparing other CDK family members. This is the first example of a PROTAC that selectively degrades CDK9.